Description

(2S,3R,4S,5R)-2,3,4,5-Tetrakis(Trimethylsilyloxy)Hexanedial Bis(o-Methyl Oxime) is a sophisticated, high-purity synthetic intermediate characterized by its multiple silyl-protected hydroxyl groups and oxime functionalities. This compound is of significant value in advanced organic synthesis, particularly for constructing complex, stereochemically defined molecular architectures where precise protection and deprotection strategies are critical. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in process chemistry and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug molecules, especially nucleoside analogs and carbohydrate-based therapeutics.
• Process Chemistry: Used in the development and scale-up of synthetic routes requiring temporary protection of multiple hydroxyl groups under mild conditions.
• Fine Chemical Synthesis: Serves as a precursor for specialty chemicals, ligands, and catalysts where specific stereochemistry is essential.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic synthesis, including new protection/deprotection methodologies and asymmetric synthesis.
• Agrochemical Intermediate: Potential use in the synthesis of advanced, stereoselective crop protection agents.

Basic Information

Product Name	(2S,3R,4S,5R)-2,3,4,5-Tetrakis(Trimethylsilyloxy)Hexanedial Bis(o-Methyl Oxime)
CAS No.	62181-81-1
Molecular Formula	C22H52N2O6Si4
Molecular Weight	561.0 g/mol (approx.)
Synonyms	Hexanedial, 2,3,4,5-tetrakis[(trimethylsilyl)oxy]-, bis(O-methyloxime), (2S,3R,4S,5R)-; D-erythro-Hexo-2,4,5,6-tetrahydroxy-1,1-bis(O-methyloxime) tetrakis(trimethylsilyl) ether; TMS-protected dialdehyde bis-oxime; Tetrakis-O-TMS dialdehyde dioxime; 2,3,4,5-Tetra-O-trimethylsilyl-D-erythro-hexodialdose bis(O-methyloxime)
EINECS	Contact for details

Quality Control

Our production of (2S,3R,4S,5R)-2,3,4,5-Tetrakis(Trimethylsilyloxy)Hexanedial Bis(o-Methyl Oxime) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to verify stereochemical purity and chemical integrity, meeting the exacting standards required for pharmaceutical R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions, preferably in a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% de (by Chiral HPLC or GC)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.