Description

1-Trimethylsilyl-1-Butyne is a versatile organosilicon building block characterized by its terminal alkyne functionality protected by a trimethylsilyl (TMS) group. This compound matters for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling efficient carbon-carbon bond formation. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating acetylene-linked scaffolds.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and plant growth regulators that require alkyne components.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of silicon-containing polymers and advanced organic materials.
• Cross-Coupling Reactions: An essential reagent in Sonogashira, Glaser, and other palladium-catalyzed coupling reactions to form conjugated systems.
• Organic Synthesis Reagent: Employed in laboratories for the protection of terminal alkynes and subsequent deprotection strategies in multi-step syntheses.
• Liquid Crystal & OLED Precursor: Used in the research and development of organic electronic materials due to its ability to introduce rigid, linear segments.

Basic Information

Product Name	1-Trimethylsilyl-1-Butyne
CAS No.	62108-37-6
Molecular Formula	C7H14Si
Molecular Weight	126.27 g/mol
Synonyms	1-Butyne, 1-(trimethylsilyl)-; Trimethyl(1-butyn-1-yl)silane; 1-Butyn-1-yltrimethylsilane; 1-Trimethylsilylbut-1-yne; TMS-Butyne; (But-1-yn-1-yl)trimethylsilane; 1-Butynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilyl-1-Butyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and highly volatile nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.