Description

Z-L-Tryptophan 2,4,5-Trichlorophenyl Ester is a protected derivative of the essential amino acid L-tryptophan, specifically designed for advanced peptide synthesis and pharmaceutical research. This compound matters as a high-purity, activated building block that enables the controlled and efficient incorporation of the tryptophan residue into complex molecular structures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of peptides, particularly where the indole side chain of tryptophan must be preserved.
• Solution-Phase Peptide Coupling: Used as an activated ester for fragment condensation strategies in the synthesis of longer peptide chains or cyclic peptides.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of therapeutic peptides targeting neurological, metabolic, and oncological pathways.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic or biochemical research applications.
• Academic and Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and the creation of novel bioactive compounds.
• Custom Synthesis Services: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized peptide sequences for clients.

Basic Information

Product Name	Z-L-Tryptophan 2,4,5-Trichlorophenyl Ester
CAS No.	62074-77-5
Molecular Formula	C25H19Cl3N2O4
Molecular Weight	517.79 g/mol
Synonyms	N-Carbobenzoxy-L-tryptophan 2,4,5-trichlorophenyl ester; Z-Trp-OCp(2,4,5-Cl3); Z-L-Trp-OCp(2,4,5-Cl3); Nα-Benzyloxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid 2,4,5-trichlorophenyl ester; CBZ-L-Tryptophan 2,4,5-Trichlorophenol Ester; Z-Tryptophan 2,4,5-Trichlorophenyl Ester; Benzyloxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester
EINECS	Contact for details

Quality Control

Our Z-L-Tryptophan 2,4,5-Trichlorophenyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and spectroscopic identification (NMR, IR). We provide comprehensive Certificates of Analysis (COA) detailing all specifications to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.