Description

(3R,5S)-4'α-Acetoxy-5-(3-Furyl)-2',3',4,4',5,6',7',8'-Octahydro-2'α-Methyl-2-Oxospiro[Furan-3(2H),1'(5'H)-Naphthalene]-5',5'-Dicarboxylic Acid Dimethyl Ester is a complex spirocyclic compound featuring a fused furan-naphthalene core structure, serving as a sophisticated synthetic intermediate. Its intricate molecular architecture makes it a valuable building block for advanced research and development in pharmaceutical chemistry, particularly for exploring novel bioactive molecules. This compound is essential for chemists and researchers in the fine chemical and pharmaceutical industries focused on synthesizing complex heterocyclic targets.

Application

• Pharmaceutical Intermediate: Key chiral building block for the research and development of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting complex biological pathways.
• Organic Synthesis Research: Used in advanced methodological studies, including spirocyclization reactions and the construction of complex polycyclic frameworks for chemical library development.
• Asymmetric Catalysis Studies: Serves as a substrate or ligand precursor in the development and testing of new chiral catalysts due to its defined stereocenters.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to investigate the impact of the spirocyclic furan-naphthalene motif on biological activity and drug-like properties.
• Fine Chemical Production: A high-value intermediate for the custom synthesis of specialty chemicals used in agrochemical or material science research.

Basic Information

Product Name	(3R,5S)-4'α-Acetoxy-5-(3-Furyl)-2',3',4,4',5,6',7',8'-Octahydro-2'α-Methyl-2-Oxospiro[Furan-3(2H),1'(5'H)-Naphthalene]-5',5'-Dicarboxylic Acid Dimethyl Ester
CAS No.	62025-46-1
Molecular Formula	C27H30O9
Molecular Weight	498.52 g/mol
Synonyms	(3R,5S)-4'α-Acetoxy-5-(3-furyl)-2',3',4,4',5,6',7',8'-octahydro-2'α-methyl-2-oxospiro[furan-3(2H),1'(5'H)-naphthalene]-5',5'-dicarboxylic acid dimethyl ester; Spiro[furan-3(2H),1'(5'H)-naphthalene] derivative, CAS 62025-46-1; Dimethyl (3R,5S)-4'α-acetoxy-5-(furan-3-yl)-2'α-methyl-2-oxooctahydro-2'H-spiro[furan-3,1'-naphthalene]-5',5'-dicarboxylate; 5',5'-Dicarboxylic Acid Dimethyl Ester, 4'α-Acetoxy-5-(3-furyl)-2',3',4,4',5,6',7',8'-octahydro-2'α-methyl-2-oxospiro[furan-3(2H),1'(5'H)-naphthalene]-, (3R,5S)-; Complex Spirocyclic Furan-Naphthalene Diester
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical identity, and impurity profiles. While not a pharmacopeial material, quality is controlled against in-house specifications developed for research-grade fine chemicals, with testing typically including HPLC, NMR, and chiral analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.