Description

Midodrine Hydrochloride is a synthetic sympathomimetic amine and a prodrug, primarily used as an active pharmaceutical ingredient (API) in the treatment of orthostatic hypotension. Its value lies in its selective α-1 adrenergic agonist activity, which increases vascular tone and blood pressure. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for autonomic nervous system disorders and related cardiovascular conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for symptomatic orthostatic hypotension.
• Clinical Research: Utilized in preclinical and clinical studies investigating autonomic dysfunction and blood pressure regulation.
• Formulation Development: Serves as a key component in the development of various oral dosage forms, such as tablets and capsules.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of finished drug products.
• Regulatory Submissions: Sourced for the preparation of drug master files (DMFs) and regulatory documentation for market approval.

Basic Information

Product Name	Midodrine Hydrochloride
CAS No.	61898-48-4
Molecular Formula	C12H18N2O4•HCl
Molecular Weight	290.74 g/mol
Synonyms	Midodrine HCl; (±)-Midodrine Hydrochloride; 2-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide Hydrochloride; ST-1085; Gutron (brand name); Amatine; Glycine, N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, amide, hydrochloride, (±)-
EINECS	Contact for details

Quality Control

Our Midodrine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A Certificate of Analysis (COA) is provided with each batch, detailing results for identity, assay, purity, and specified impurities. We can supply material compliant with various pharmacopeial standards, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.