Description

Hydroxymelphalan is a bifunctional alkylating agent and a derivative of the nitrogen mustard class of chemotherapeutic compounds. This compound is of significant interest in pharmaceutical research and development, particularly in the synthesis of novel anti-cancer agents and as a key intermediate for targeted therapies. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery and the production of high-potency active pharmaceutical ingredients (HPAPIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced chemotherapeutic agents and targeted cancer therapies.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of alkylation and DNA cross-linking in cancer cells.
• HPAPI Manufacturing: Serves as a key precursor in the controlled production of high-potency active pharmaceutical ingredients requiring specialized handling.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Preclinical Development: Utilized in the formulation and testing of new drug candidates during early-stage development phases.

Basic Information

Product Name	Hydroxymelphalan
CAS No.	61733-01-5
Molecular Formula	C14H19Cl2N3O3
Molecular Weight	348.22 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]-L-phenylalanine, 1-hydroxy derivative; L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, 1-hydroxy-; Hydroxy Melphalan; NSC-113233; 1-Hydroxymelphalan; 4-[Bis(2-chloroethyl)amino]-1-hydroxy-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Hydroxymelphalan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing specific results for each parameter are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.