Description

tert-Butyldimethyl(4-Pentynyloxy)Silane is a specialized organosilicon compound featuring a terminal alkyne functional group, making it a valuable building block in advanced organic synthesis. Its primary value lies in its dual functionality, serving as a robust silicon protecting group while providing a reactive alkyne handle for further chemical transformations, such as click chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for coupling via Huisgen 1,3-dipolar cycloaddition (click chemistry) reactions.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the alkyne moiety enables modular construction of active molecules.
• Polymer & Materials Science: Serves as a functional monomer or cross-linking agent for creating silicon-containing polymers, dendrimers, and surface-modified materials.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group effectively protects alcohols during multi-step synthetic sequences, with the pentynyloxy tether allowing for selective deprotection or further conjugation.
• Bioconjugation: Facilitates the labeling and modification of biomolecules (proteins, peptides, nucleic acids) for diagnostic and therapeutic applications.
• Ligand & Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis and organometallic complexes.

Basic Information

Product Name	tert-Butyldimethyl(4-Pentynyloxy)Silane
CAS No.	61362-77-4
Molecular Formula	C11H22OSi
Molecular Weight	198.38 g/mol
Synonyms	4-Pentynyloxy-tert-butyldimethylsilane; (4-Pentynyloxy)(tert-butyl)dimethylsilane; tert-Butyl(4-pentynyloxy)dimethylsilane; TBDMS 4-pentynyl ether; 4-(tert-Butyldimethylsilyloxy)-1-butyne; 1-((tert-Butyldimethylsilyl)oxy)-4-pentyne; Silane, tert-butyldimethyl(4-pentynyloxy)-; 4-Pentyn-1-ol, 1-(1,1-dimethylethyl)-1,1-dimethylsilyl ether
EINECS	Contact for details

Quality Control

Our tert-Butyldimethyl(4-Pentynyloxy)Silane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality assurance ensures the material meets the high standards required for research and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.