Description

Trimethylsilyl tert-Butylacetate is a versatile organosilicon reagent used as a protecting group agent and a key synthetic intermediate. Its primary value lies in enabling complex organic transformations, particularly in the synthesis of sensitive pharmaceutical compounds and advanced materials. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for sophisticated synthesis.

Application

• Pharmaceutical Synthesis: As a protecting group for carboxylic acids in multi-step synthesis of active pharmaceutical ingredients (APIs).
• Peptide Chemistry: For the temporary protection of amino acid side chains during solid-phase and solution-phase peptide synthesis.
• Agrochemical Intermediate: Used in the production of advanced herbicides and fungicides that require specific steric and electronic properties.
• Material Science Precursor: Serves as a monomer or modifying agent in the synthesis of specialized silicone-based polymers and coatings.
• Organic Synthesis Reagent: Facilitates reactions where standard ester protection methods are incompatible, offering orthogonal deprotection strategies.
• Chemical Research: A valuable tool in academic and industrial R&D for developing new synthetic methodologies and exploring novel compound libraries.

Basic Information

Product Name	Trimethylsilyl tert-Butylacetate
CAS No.	61333-82-2
Molecular Formula	C9H20O2Si
Molecular Weight	188.34 g/mol
Synonyms	tert-Butyl 2-(Trimethylsilyl)acetate; 2-(Trimethylsilyl)acetic Acid tert-Butyl Ester; Acetic Acid, 2-(Trimethylsilyl)-, 1,1-Dimethylethyl Ester; (Trimethylsilyl)acetic Acid tert-Butyl Ester; TMS-tert-Butyl Acetate; TBDMS Acetate; tert-Butyl Trimethylsilylacetate
EINECS	Contact for details

Quality Control

Our Trimethylsilyl tert-Butylacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.