Description

(4R)-(+)-T-Butyldimethylsiloxy-2-Cyclopenten-1-One is a high-value, chiral building block and key synthetic intermediate in organic chemistry. Its primary value lies in its role as a versatile precursor for the stereoselective synthesis of complex natural products and pharmaceutical agents, particularly prostaglandins and other bioactive molecules. This compound is essential for research and development laboratories, as well as production facilities, in the pharmaceutical, agrochemical, and fine chemical industries where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of prostaglandin analogs and other bioactive compounds with defined stereocenters.
• Asymmetric Synthesis: Used in stereocontrolled reactions, including aldol and Michael additions, to construct complex molecular architectures.
• Natural Product Synthesis: Serves as a key starting material in the total synthesis of terpenoids and other natural products.
• Agrochemical Research: Employed in the development of chiral active ingredients for crop protection agents.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and catalysis studies.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	(4R)-(+)-T-Butyldimethylsiloxy-2-Cyclopenten-1-One
CAS No.	61305-35-9
Molecular Formula	C11H20O2Si
Molecular Weight	212.36 g/mol
Synonyms	(4R)-4-[(tert-Butyldimethylsilyl)oxy]-2-cyclopenten-1-one; (R)-4-(tert-Butyldimethylsiloxy)-2-cyclopenten-1-one; (4R)-4-(Tert-butyldimethylsiloxy)-2-cyclopenten-1-one; (R)-TBDMS-oxy-2-cyclopentenone; (4R)-(+)-4-(tert-Butyldimethylsilyloxy)-2-cyclopenten-1-one; (R)-4-(TBDMSO)-2-cyclopentenone; 4-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-cyclopenten-1-one, (4R)-; (4R)-4-[(tert-Butyldimethylsilyl)oxy]cyclopent-2-en-1-one
EINECS	Contact for details

Quality Control

Our (4R)-(+)-T-Butyldimethylsiloxy-2-Cyclopenten-1-One is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR, and IR spectroscopy for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.