Description

4-(3-Hydroxy-Prop-1-Ynyl)-Benzoic Acid Methyl Ester is a versatile organic building block featuring both a terminal alkyne and a methyl ester functional group. This bifunctional nature makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring alkyne-based coupling reactions.
• Organic Synthesis Building Block: Used in Sonogashira, Huisgen cycloaddition (click chemistry), and other cross-coupling reactions to introduce functionalized aromatic systems.
• Liquid Crystal & Advanced Material Research: Serves as a monomer or intermediate for creating novel polymers and organic electronic materials with specific optical properties.
• Agrochemical Synthesis: Employed in the development and production of new generation herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Bioconjugation: The alkyne group enables bioorthogonal labeling strategies for probing biological systems and developing diagnostic tools.
• Academic & Contract Research: Essential for fundamental organic chemistry research and custom synthesis projects in university and CRO laboratories.

Basic Information

Product Name	4-(3-Hydroxy-Prop-1-Ynyl)-Benzoic Acid Methyl Ester
CAS No.	61266-36-2
Molecular Formula	C11H10O3
Molecular Weight	190.20 g/mol
Synonyms	Methyl 4-(3-hydroxyprop-1-yn-1-yl)benzoate; Benzoic acid, 4-(3-hydroxy-1-propynyl)-, methyl ester; 4-(3-Hydroxyprop-1-ynyl)benzoic acid methyl ester; Methyl 4-(3-hydroxypropynyl)benzoate; p-(3-Hydroxy-1-propynyl)benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-(3-Hydroxy-Prop-1-Ynyl)-Benzoic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.