Description

3-Ethyl-3-Methyl-1-Trimethylsilyl-1-Pentyne is a specialized organosilicon building block featuring a protected terminal alkyne functionality. This compound is valued for its role in advanced organic synthesis, particularly in cross-coupling and cycloaddition reactions where the trimethylsilyl (TMS) group acts as a versatile protecting and directing moiety. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for creating complex alkynes and heterocycles.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its reactivity to form carbon-carbon bonds.
• Material Science Research: Serves as a precursor for functionalized polymers, dendrimers, and organic electronic materials via controlled polymerization or grafting reactions.
• Cross-Coupling Reactions: Employed in Sonogashira, Heck, and other palladium-catalyzed couplings to introduce alkyne segments into target molecules.
• Click Chemistry: The protected alkyne can be deprotected in situ for use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) to create triazole linkages.
• Organic Synthesis Building Block: Provides a versatile handle for further functionalization in multi-step synthetic routes for complex natural products and fine chemicals.

Basic Information

Product Name	3-Ethyl-3-Methyl-1-Trimethylsilyl-1-Pentyne
CAS No.	61228-00-0
Molecular Formula	C11H22Si
Molecular Weight	182.38 g/mol
Synonyms	1-Trimethylsilyl-3-ethyl-3-methyl-1-pentyne; 3-Ethyl-3-methyl-1-(trimethylsilyl)-1-pentyne; 3-Ethyl-3-methyl-1-(trimethylsilyl)pentyne; (3-Ethyl-3-methylpent-1-yn-1-yl)trimethylsilane; Trimethyl[(3-ethyl-3-methylpent-1-yn-1-yl)]silane; TMS-protected 3-ethyl-3-methylpentyne
EINECS	Contact for details

Quality Control

Our 3-Ethyl-3-Methyl-1-Trimethylsilyl-1-Pentyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.