Description

3,3-Dimethyl-1-Trimethylsilyl-1-Pentyne is a specialized organosilicon building block featuring a terminal alkyne group protected by a trimethylsilyl (TMS) moiety. This compound is valued for its role as a key synthetic intermediate in advanced organic and organometallic chemistry, enabling precise carbon-carbon bond formation. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing acetylene units in a protected form.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the alkyne functionality is essential for biological activity.
• Material Science Research: Employed in the development of advanced polymers, dendrimers, and organic electronic materials via click chemistry and other alkyne-based coupling reactions.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Glaser, and other palladium-catalyzed cross-coupling reactions to form conjugated systems.
• Organometallic Chemistry: Used to prepare metal acetylide complexes which are catalysts or precursors in various synthetic transformations.
• Chemical Research & Development: A versatile reagent for organic synthesis in academic and industrial R&D laboratories for exploring new synthetic methodologies.

Basic Information

Product Name	3,3-Dimethyl-1-Trimethylsilyl-1-Pentyne
CAS No.	61227-97-2
Molecular Formula	C10H20Si
Molecular Weight	168.35 g/mol
Synonyms	1-Trimethylsilyl-3,3-dimethyl-1-pentyne; 3,3-Dimethyl-1-(trimethylsilyl)-1-pentyne; (3,3-Dimethyl-1-pentyn-1-yl)trimethylsilane; TMS-Protected 3,3-Dimethyl-1-pentyne; Trimethyl(3,3-dimethyl-1-pentyn-1-yl)silane; TMS acetylene derivative
EINECS	Contact for details

Quality Control

Our 3,3-Dimethyl-1-Trimethylsilyl-1-Pentyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee the product meets your specific research or process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile and hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.