Description

Dimethyl (Boc-Amino)Malonate is a versatile and high-purity protected amino acid derivative, widely recognized as a crucial building block in organic synthesis. Its primary value lies in its role as a key intermediate for the efficient introduction of the Boc-protected glycine moiety, enabling the synthesis of complex peptides and other biologically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of peptide-based drugs, protease inhibitors, and other complex APIs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate protected glycine analogs.
• Agrochemical Research: Serves as a key intermediate in the development of novel herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, chiral auxiliaries, and advanced materials.
• Academic & R&D: A valuable reagent for medicinal chemistry research, method development, and exploring new synthetic pathways.
• Bioconjugation Chemistry: Useful for creating linkers and modifying biomolecules due to its reactive ester groups and protected amine.

Basic Information

Product Name	Dimethyl (Boc-Amino)Malonate
CAS No.	61172-70-1
Molecular Formula	C11H19NO6
Molecular Weight	261.27 g/mol
Synonyms	Dimethyl N-(tert-Butoxycarbonyl)aminomalonate; (Boc-Amino)malonic Acid Dimethyl Ester; N-Boc-Aminomalonic Acid Dimethyl Ester; tert-Butyl (Dimethoxyphosphoryl)glycinate (common misnomer); Boc-Aminomalonic Acid Dimethyl Ester; N-(tert-Butoxycarbonyl)aminomalonic Acid Dimethyl Ester; Dimethyl 2-[(tert-butoxycarbonyl)amino]propanedioate; 2-((tert-Butoxycarbonyl)amino)malonic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our Dimethyl (Boc-Amino)Malonate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.