Description

(Z)-2-(1H-Indol-3-Yl)Vinyl Isocyanide is a specialized, high-value organic building block featuring a reactive isocyanide group conjugated with an indole moiety. This compound matters as a critical intermediate for constructing complex heterocyclic frameworks, particularly in the synthesis of novel pharmaceuticals and advanced materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for lead optimization and the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex alkaloids and heterocyclic compounds with potential biological activity.
• Agrochemical Research: Used in the synthesis of novel active ingredients for crop protection and pest management.
• Material Science: Serves as a monomer or precursor for functional polymers and advanced organic electronic materials.
• Chemical Biology: Employed in the development of chemical probes and bio-conjugation tools due to its reactive isocyanide functionality.
• Academic & Contract Research: Essential for methodological development in organic synthesis, including multicomponent reactions (MCRs) like the Ugi and Passerini reactions.
• Dye & Pigment Synthesis: Used as a precursor for indole-based chromophores and fluorescent markers.

Basic Information

Product Name	(Z)-2-(1H-Indol-3-Yl)Vinyl Isocyanide
CAS No.	61168-06-7
Molecular Formula	C11H8N2
Molecular Weight	168.20 g/mol
Synonyms	(Z)-3-(2-Isocyanoethenyl)-1H-indole; (Z)-3-(2-Isocyanoethenyl)indole; 3-[(1Z)-2-Isocyanoethenyl]-1H-indole; (Z)-2-(1H-Indol-3-yl)ethenyl isocyanide; (Z)-2-(1H-Indol-3-yl)vinyl isocyanide; (Z)-3-(2-Isocyanoethenyl)-1H-indole; 1H-Indole, 3-[(1Z)-2-isocyanoethenyl]-; (Z)-2-(Indol-3-yl)vinyl isocyanide
EINECS	Contact for details

Quality Control

Our (Z)-2-(1H-Indol-3-Yl)Vinyl Isocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles for the production of high-purity research chemicals, ensuring reliable and reproducible results for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). For long-term stability, storage under an inert atmosphere (e.g., nitrogen or argon) is recommended. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Light yellow to yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.