Description

[(1α,4β)-4-[3-(2-Chloroethyl)-3-Nitrosoureido]Cyclohexyl]Acetic Acid Methyl Ester is a specialized synthetic intermediate of significant interest in advanced organic synthesis and pharmaceutical research. Its complex molecular architecture, featuring a nitrosourea moiety linked to a cyclohexylacetic acid ester, makes it a valuable precursor for constructing biologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical development companies engaged in the discovery and synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in oncology research due to the presence of the nitrosourea functional group.
• Biochemical Research: Used in the study of alkylating agents and their mechanisms of action, as well as in proteomics and enzyme inhibition studies.
• Organic Synthesis: Acts as a key precursor for the preparation of more complex heterocyclic compounds and targeted molecular scaffolds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new chemical entities with potential therapeutic value.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	[(1α,4β)-4-[3-(2-Chloroethyl)-3-Nitrosoureido]Cyclohexyl]Acetic Acid Methyl Ester
CAS No.	61137-49-3
Molecular Formula	C₁₂H₂₀ClN₃O₄
Molecular Weight	305.76 g/mol
Synonyms	Methyl (1α,4β)-4-[3-(2-chloroethyl)-3-nitrosoureido]cyclohexaneacetate; Methyl 4-[N-(2-chloroethyl)-N-nitrosocarbamoylamino]cyclohexylacetate; 1-Cyclohexaneacetic acid, 4-[[[3-(2-chloroethyl)-3-nitrosoureido]-, methyl ester, (1α,4β)-; Methyl trans-4-[3-(2-chloroethyl)-3-nitrosoureido]cyclohexylacetate; Nitrosourea CCNU derivative ester; Lomustine analog intermediate
EINECS	Contact for details

Quality Control

Our [(1α,4β)-4-[3-(2-Chloroethyl)-3-Nitrosoureido]Cyclohexyl]Acetic Acid Methyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We adhere to cGMP guidelines where applicable to meet the stringent requirements of pharmaceutical and research customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature, handling and storage should minimize exposure to direct light. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.