Description

(2R,3R)-Diethyl 1,4-Dioxaspiro[4.5]Decane-2,3-Dicarboxylate is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its well-defined stereochemistry and functional group array, enabling the precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in antiviral, cardiovascular, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of chiral pesticides and herbicides, where specific stereochemistry is crucial for biological activity and environmental safety.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands and organocatalysts used in stereoselective transformations.
• Fine Chemical & Specialty Polymer Building Block: Employed in the synthesis of complex fine chemicals, flavors, fragrances, and monomers for advanced polymers with specific stereochemical properties.
• Academic & Process Chemistry Research: A valuable tool in methodological development for new asymmetric synthesis routes and scale-up process optimization studies.

Basic Information

Product Name	(2R,3R)-Diethyl 1,4-Dioxaspiro[4.5]Decane-2,3-Dicarboxylate
CAS No.	61045-33-8
Molecular Formula	C15H24O6
Molecular Weight	300.35 g/mol
Synonyms	(2R,3R)-Diethyl 2,3-O-Isopropylidene-L-tartrate; (2R,3R)-Diethyl 2,3-O-(1-Methylethylidene)-L-tartrate; Diethyl (2R,3R)-2,3-O-Isopropylidene-L-tartrate; (2R,3R)-(-)-Diethyl 2,3-O-Isopropylidene Tartrate; L-(-)-Diethyl 2,3-O-Isopropylidene Tartrate; (2R,3R)-Diethyl 2,3-O-(1-Methylethylidene)tartrate; (2R,3R)-1,4-Dioxaspiro[4.5]decane-2,3-dicarboxylic acid, diethyl ester
EINECS	Contact for details

Quality Control

Our (2R,3R)-Diethyl 1,4-Dioxaspiro[4.5]Decane-2,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]D20	-15° to -18° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.