Description

Tolyl 2,3,4-Tri-o-Acetyl-1-Thio-β-D-Glucuronic Acid Methyl Ester, Thiocresyl 2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester CAS NO 61025-09-0 is a key thioglycoside derivative and a protected form of a glucuronic acid analog. This compound serves as a critical synthetic intermediate and biochemical tool, particularly valuable for its role in conjugation chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in drug metabolism studies, prodrug development, and the synthesis of complex glycoconjugates.

Application

• Synthetic Intermediate for Prodrugs: Used in the design and synthesis of prodrugs to enhance drug solubility, stability, and targeted delivery.
• Bioconjugation and Labeling: Acts as a versatile building block for attaching glucuronic acid moieties to various molecules, including drugs, peptides, and fluorescent probes.
• Biochemical Research: Employed in enzymatic studies, particularly those involving β-glucuronidases, to investigate metabolic pathways and enzyme inhibition.
• Glycochemistry and Glycobiology: Serves as a protected precursor for the synthesis of more complex oligosaccharides and glycoconjugates of biological interest.
• Reference Standard: Utilized as a high-purity analytical standard in pharmaceutical quality control and metabolic research laboratories.

Basic Information

Item	Details
Product Name	Tolyl 2,3,4-Tri-o-Acetyl-1-Thio-β-D-Glucuronic Acid Methyl Ester, Thiocresyl 2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester
CAS No.	61025-09-0
Molecular Formula	C₂₀H₂₄O₁₀S
Molecular Weight	456.46 g/mol
Synonyms	Methyl (2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosid)uronate; p-Tolyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosiduronate; Thiocresyl glucuronate triacetate; 1-Thio-β-D-glucuronic acid methyl ester 2,3,4-triacetate; p-Methylphenyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosiduronate; 4-Methylphenyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosiduronate
EINECS	Contact for details

Quality Control

Our production of this advanced biochemical adheres to stringent quality protocols. Each batch undergoes comprehensive analysis, including HPLC for purity verification and identity confirmation by spectroscopic methods. A Certificate of Analysis (COA) detailing specific results for assay, related substances, and residual solvents is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and purity. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.