Description

1,1'-Hexamethylenebis[3-(2-Chloroethyl)-3-Nitrosourea] is a specialized bifunctional nitrosourea derivative, a class of compounds known for their alkylating properties. This compound is valued in advanced research and development for its potential as a key synthetic intermediate or a biochemical tool. It is primarily of interest to researchers and developers in the pharmaceutical and life sciences sectors, particularly those working on novel therapeutic agents or studying DNA alkylation mechanisms.

Application

• Pharmaceutical Research & Development: Serves as a critical synthetic intermediate in the development of novel chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Used as a tool compound in laboratory studies to investigate DNA alkylation, cross-linking mechanisms, and cellular apoptosis pathways.
• Antitumor Agent Development: Acts as a precursor or model compound for the synthesis and evaluation of new nitrosourea-based antitumor drugs.
• Academic Research: Employed in university and institutional laboratories for fundamental studies in medicinal chemistry and oncology.
• Process Chemistry: Utilized in scale-up and optimization studies for the production of specialized active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1,1'-Hexamethylenebis[3-(2-Chloroethyl)-3-Nitrosourea]
CAS No.	60784-45-4
Molecular Formula	C₁₄H₂₄Cl₂N₆O₄
Molecular Weight	411.28 g/mol
Synonyms	1,1'-Hexamethylenebis(3-(2-chloroethyl)-3-nitrosourea); BCNU Dimer; Carmustine Dimer; 1,1'-(Hexane-1,6-diyl)bis(3-(2-chloroethyl)-1-nitrosourea); HN2-BCNU; Bis-chloroethylnitrosourea hexamethylene derivative
EINECS	Contact for details

Quality Control

Our 1,1'-Hexamethylenebis[3-(2-Chloroethyl)-3-Nitrosourea] is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.