Description

4-[4-(Trifluoromethyl)Phenyl]Pyridin-2-Amine CAS NO 60781-91-1 is a high-value, functionalized pyridine derivative characterized by a trifluoromethylphenyl substituent, making it a versatile and sought-after building block in advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture to impart specific properties like metabolic stability and lipophilicity to their final products. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials, serving the needs of the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and antiviral agent discovery.
• Agrochemical Synthesis: Used as a core building block for creating advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis for fine chemical production.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring this specific chemical scaffold.

Basic Information

Product Name	4-[4-(Trifluoromethyl)Phenyl]Pyridin-2-Amine
CAS No.	60781-91-1
Molecular Formula	C12H9F3N2
Molecular Weight	238.21 g/mol
Synonyms	2-Amino-4-[4-(trifluoromethyl)phenyl]pyridine; 4-(4-Trifluoromethylphenyl)-2-pyridinamine; 4-(4-Trifluoromethylphenyl)pyridin-2-amine; 2-Pyridinamine, 4-[4-(trifluoromethyl)phenyl]-; 4-(α,α,α-Trifluoro-p-tolyl)-2-aminopyridine; 4-(4-Trifluoromethylphenyl)-2-aminopyridine; 4-(4-Trifluoromethylphenyl)-2-pyridylamine
EINECS	Contact for details

Quality Control

Our 4-[4-(Trifluoromethyl)Phenyl]Pyridin-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.