Description

2-Benzamido-3-(4-(N,n-Bis-(2-Chloroethyl)Amino)Phenyl)Propionic Acid is a specialized synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its structural complexity, which incorporates functional groups amenable to further chemical modification. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within oncology and targeted drug delivery systems. The compound's precise molecular architecture makes it a critical building block for developing next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex, nitrogen mustard-based chemotherapeutic agents and targeted cancer therapies.
• Bioconjugation Research: Used in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery platforms due to its reactive chloroethylamino groups.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies in the discovery of new anticancer and alkylating agents.
• Biochemical Research: Employed in studies investigating DNA alkylation mechanisms and the design of enzyme inhibitors.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	2-Benzamido-3-(4-(N,n-Bis-(2-Chloroethyl)Amino)Phenyl)Propionic Acid
CAS No.	60557-40-6
Molecular Formula	C20H22Cl2N2O3
Molecular Weight	409.31 g/mol
Synonyms	N-Benzoyl-3-[4-[bis(2-chloroethyl)amino]phenyl]alanine; 2-Benzamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; L-Phenylalanine, N-benzoyl-3-[4-[bis(2-chloroethyl)amino]phenyl]-; Benzamide, N-[1-carboxy-2-[4-[bis(2-chloroethyl)amino]phenyl]ethyl]-; 60557-40-6; NSC 338947
EINECS	Contact for details

Quality Control

Every batch of 2-Benzamido-3-(4-(N,n-Bis-(2-Chloroethyl)Amino)Phenyl)Propionic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, purity, and specified impurities. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.