Description

(17R)-3β-Hydroxyspiro[Androst-5-Ene-17,1'-Cyclobutan]-2'-One is a high-purity, steroidal spiro compound characterized by its unique cyclobutanone ring fused to the androstane core. This specific molecular architecture makes it a valuable advanced pharmaceutical intermediate (API Intermediate) for research and development in medicinal chemistry. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in steroid analysis.
• Biochemical Research: Investigated for its potential interactions with steroid hormone receptors and related biological pathways.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex steroid molecules.

Basic Information

Product Name	(17R)-3β-Hydroxyspiro[Androst-5-Ene-17,1'-Cyclobutan]-2'-One
CAS No.	60534-16-9
Molecular Formula	C22H32O2
Molecular Weight	328.49 g/mol
Synonyms	3β-Hydroxyspiro[androst-5-ene-17,1'-cyclobutan]-2'-one; (17R)-3β-Hydroxyspiro[androst-5-ene-17,1'-cyclobutan]-2'-one; Spiro[androst-5-ene-17,1'-cyclobutan]-2'-one, 3β-hydroxy-, (17R)-; 3β-Hydroxy-17,17-cyclobutanandrost-5-en-2-one; 17,17-Cyclobutanandrost-5-en-3β-ol-2-one
EINECS	Contact for details

Quality Control

Our (17R)-3β-Hydroxyspiro[Androst-5-Ene-17,1'-Cyclobutan]-2'-One is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.