Description

2-(Chlorocarbonyl)-6-Methylpyridine Hydrochloride, also known as 6-Methylpicolinoyl Chloride Hydrochloride, is a high-value, reactive acid chloride derivative used as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of the 6-methylpicolinoyl moiety, a key structural motif in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), fine chemicals, and specialized materials. The CAS number for this compound is 60373-34-4.

Application

This versatile chemical intermediate is primarily employed in the synthesis of complex molecules across several high-tech industries.

• Pharmaceutical Intermediates: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific pyridine-based structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and other functional materials.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-(Chlorocarbonyl)-6-Methylpyridine Hydrochloride
CAS No.	60373-34-4
Molecular Formula	C7H7Cl2NO
Molecular Weight	192.04 g/mol
Synonyms	6-Methylpicolinoyl Chloride Hydrochloride; 6-Methylpyridine-2-carbonyl Chloride Hydrochloride; 2-Carbamoyl-6-methylpyridine Hydrochloride Chloride; 6-Methyl-2-pyridinecarbonyl Chloride Hydrochloride; 2-Pyridinecarbonyl chloride, 6-methyl-, hydrochloride; 6-Methylpicolinic acid chloride hydrochloride
EINECS	Contact for details

Quality Control

Our production of 2-(Chlorocarbonyl)-6-Methylpyridine Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. All materials are manufactured and tested in facilities that implement current Good Manufacturing Practices (cGMP) principles where applicable. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as purity (HPLC), identity (IR, NMR), and impurity profiles. We support custom synthesis and purity grades to meet specific project requirements, from research quantities to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The compound is incompatible with strong bases, strong oxidizing agents, and water. Handle and store in a well-ventilated area, using appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.