Description

2-Iodo-3-Methyl-4-Nitropyridine n-Oxide is a versatile and highly functionalized heterocyclic building block, primarily valued for its role in advanced organic synthesis and pharmaceutical research. Its unique structure, featuring iodine, nitro, and N-oxide functionalities, makes it a critical intermediate for constructing complex molecules and exploring novel chemical space. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing functionalized pyridine cores.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Ligand Synthesis: Acts as a starting material for the preparation of specialized ligands used in catalysis and coordination chemistry.
• Material Science: Employed in the research and development of advanced organic electronic materials and dyes.
• Cross-Coupling Reactions: The iodine substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Functional Group Transformation: Utilized in medicinal chemistry for the strategic modification of the nitro and N-oxide groups to introduce amines, amides, or other functionalities.

Basic Information

Product Name	2-Iodo-3-Methyl-4-Nitropyridine n-Oxide
CAS No.	60324-00-7
Molecular Formula	C6H5IN2O3
Molecular Weight	280.02 g/mol
Synonyms	2-Iodo-3-methyl-4-nitropyridine 1-oxide; 3-Methyl-4-nitro-2-iodopyridine N-oxide; 4-Nitro-3-methyl-2-iodopyridine N-oxide; 2-Iodo-3-methyl-4-nitropyridine N-oxide; Pyridine, 2-iodo-3-methyl-4-nitro-, 1-oxide; 60324-00-7 (CAS); 2-Iodo-3-methyl-4-nitropyridine oxide
EINECS	Contact for details

Quality Control

Our 2-Iodo-3-Methyl-4-Nitropyridine n-Oxide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.