Description

2-Bromo-3-Methyl-4-Nitropyridine 1-Oxide is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, nitro, and N-oxide functional groups on a methylated pyridine core, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Research: Serves as a building block in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging its reactive halogen and nitro groups for further functionalization.
• Ligand and Catalyst Development: Used in the research and development of specialized ligands for metal catalysis and organocatalysts due to the electron-withdrawing and coordinating properties of the N-oxide moiety.
• Material Science Precursor: Employed in the synthesis of functionalized polymers and advanced organic materials that require specific pyridine-based monomers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl and conjugated systems.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups allow for sequential displacement reactions, enabling the introduction of diverse amines, alkoxides, and other nucleophiles.

Basic Information

Product Name	2-Bromo-3-Methyl-4-Nitropyridine 1-Oxide
CAS No.	60323-97-9
Molecular Formula	C6H5BrN2O3
Molecular Weight	233.02 g/mol
Synonyms	2-Bromo-3-methyl-4-nitropyridine N-oxide; 3-Methyl-4-nitro-2-bromopyridine 1-oxide; 4-Nitro-3-methyl-2-bromopyridine N-oxide; Pyridine, 2-bromo-3-methyl-4-nitro-, 1-oxide; 2-Bromo-3-methyl-4-nitropyridine N-Oxide; 2-Bromo-3-methyl-4-nitropyridine oxide; 60323-97-9
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Methyl-4-Nitropyridine 1-Oxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.