Description

Dimethyl 1,4-Dihydro-2,6-Dimethyl-4-(2-Nitrophenyl)Pyridine-3,5-Dicarboxylate Monohydrochloride is a high-purity pharmaceutical intermediate and research chemical. This compound is valued for its role as a key synthetic precursor in the development of calcium channel blockers and other active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in cardiovascular drug discovery and organic synthesis.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of Nifedipine and related 1,4-dihydropyridine (DHP) class calcium channel blockers.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new cardiovascular therapeutics.
• Fine Chemical Synthesis: Serves as a building block for creating complex molecules with potential biological activity in contract research organizations (CROs).
• Academic Research: Employed in university laboratories for studying heterocyclic chemistry, nitro-group reduction, and esterification reactions.
• Analytical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	Dimethyl 1,4-Dihydro-2,6-Dimethyl-4-(2-Nitrophenyl)Pyridine-3,5-Dicarboxylate Monohydrochloride
CAS No.	60299-11-8
Molecular Formula	C17H19N2O6Cl
Molecular Weight	382.80 g/mol
Synonyms	Nifedipine Impurity; Nifedipine Related Compound; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Dimethyl Ester Hydrochloride; Dimethyl 4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride; BAY a 1040 Impurity; DHP Nitro Ester Hydrochloride; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester, hydrochloride
EINECS	Contact for details

Quality Control

Our Dimethyl 1,4-Dihydro-2,6-Dimethyl-4-(2-Nitrophenyl)Pyridine-3,5-Dicarboxylate Monohydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.