Description

4α-[3-(2-Chloroethyl)-3-Nitrosoureido]-1α-Cyclohexanecarboxylic Acid Methyl Ester is a specialized nitrosourea derivative with significant potential in advanced organic synthesis and pharmaceutical research. This compound matters for its role as a key intermediate in the development of novel therapeutic agents, particularly in oncology research where nitrosourea compounds are studied. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing new chemical entities and targeted drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anticancer agents and other biologically active molecules.
• Oncology Research: Used in academic and industrial research to study the structure-activity relationships of nitrosourea-based chemotherapeutic compounds.
• Medicinal Chemistry: Employed in the design and development of new drug candidates targeting specific cellular pathways.
• Fine Chemical Synthesis: Acts as a specialized reagent for introducing the nitrosourea functional group into complex molecular architectures.
• Bioconjugation Studies: Potential use in developing targeted drug delivery systems and antibody-drug conjugates (ADCs).
• Chemical Biology Probes: Utilized to create tools for investigating enzyme mechanisms and cellular processes.

Basic Information

Product Name	4α-[3-(2-Chloroethyl)-3-Nitrosoureido]-1α-Cyclohexanecarboxylic Acid Methyl Ester
CAS No.	60285-32-7
Molecular Formula	C11H18ClN3O4
Molecular Weight	291.73 g/mol
Synonyms	Methyl 4α-[3-(2-chloroethyl)-3-nitrosoureido]-1α-cyclohexanecarboxylate; 1α-Cyclohexanecarboxylic acid, 4α-[3-(2-chloroethyl)-3-nitrosoureido]-, methyl ester; NSC 338947; 4α-[N'-(2-Chloroethyl)-N-nitrosoureido]-1α-cyclohexanecarboxylic acid methyl ester; Methyl 4α-[[(2-chloroethyl)nitrosoamino]carbonylamino]-1α-cyclohexanecarboxylate; Nitrosourea CCNU derivative; Lomustine analog intermediate
EINECS	Contact for details

Quality Control

Our production of 4α-[3-(2-Chloroethyl)-3-Nitrosoureido]-1α-Cyclohexanecarboxylic Acid Methyl Ester adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and structural confirmation via NMR and MS. Certificates of Analysis (COA) detailing batch-specific results are available upon request, ensuring full traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature, the container should be opaque or stored in dark conditions. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.