Description

Ethyl(R)-Nipecotatel-Tartarate is a high-purity chiral intermediate and salt form of a nipecotic acid derivative. This compound is of significant value in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals where stereochemical purity is critical. It is primarily needed by pharmaceutical R&D laboratories, process development chemists, and manufacturers of advanced intermediates for the production of central nervous system (CNS) targeted drugs and other specialized therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of GABA receptor modulators and other neurologically active compounds.
• Asymmetric Synthesis: Used as a precursor or resolving agent in stereoselective chemical reactions to control the formation of specific enantiomers.
• API Development: Employed in the research and process development of new chemical entities (NCEs), particularly in early-stage drug discovery.
• Fine Chemical Production: Serves as a specialized intermediate for the manufacture of high-value, complex organic molecules.
• Chemical Reference Standard: Can be utilized as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Ethyl(R)-Nipecotatel-Tartarate
CAS No.	60218-49-7
Molecular Formula	C13H23NO8
Molecular Weight	321.33 g/mol
Synonyms	(R)-Ethyl Nipecotate L-Tartrate; (R)-1-Ethyl 3-Carboxylate Piperidine L-Tartrate; Ethyl (R)-3-Piperidinecarboxylate L-Tartrate; (R)-Nipecotic Acid Ethyl Ester Tartrate; (R)-Ethyl Nipecotate Tartaric Acid Salt; (R)-1-Carbethoxy-3-piperidinecarboxylic Acid Tartrate; (3R)-1-Ethyl Piperidine-3-carboxylate (2R,3R)-2,3-Dihydroxysuccinate
EINECS	Contact for details

Quality Control

Our Ethyl(R)-Nipecotatel-Tartarate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. A Certificate of Analysis (COA) detailing results for assay, chiral purity, residual solvents, and related substances is provided with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.