Description

Propanoic Acid, 3,3,3-Trifluoro-2-Hydroxy-2-Methyl-, Methyl Ester, (±)- is a specialized fluorinated organic ester, a key chiral building block in advanced chemical synthesis. Its unique trifluoromethyl and hydroxyl groups adjacent to the ester functionality make it a valuable intermediate for introducing fluorinated motifs, which are critical for modulating the physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated building block for electronic chemicals used in display technologies, enhancing dielectric anisotropy and stability.
• Advanced Polymer Modification: Incorporated as a monomer or modifier to create fluorinated polymers with unique surface properties, chemical resistance, and thermal stability.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new catalytic systems for stereoselective synthesis.
• Protease Inhibitor Development: The α-hydroxy-β-trifluoromethyl ester motif is valuable for constructing transition-state analogs in protease inhibitor research.

Basic Information

Product Name	Propanoic Acid, 3,3,3-Trifluoro-2-Hydroxy-2-Methyl-, Methyl Ester, (±)-
CAS No.	60200-63-7
Molecular Formula	C6H9F3O3
Molecular Weight	186.13 g/mol
Synonyms	Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropionate; (±)-Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate; 3,3,3-Trifluoro-2-hydroxy-2-methylpropionic acid methyl ester; Methyl 2-hydroxy-2-methyl-3,3,3-trifluoropropionate; 2-Methyl-2-hydroxy-3,3,3-trifluoropropionic acid methyl ester; DL-Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropionate; α-Hydroxy-α-methyl-β,β,β-trifluoropropionic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Propanoic Acid, 3,3,3-Trifluoro-2-Hydroxy-2-Methyl-, Methyl Ester, (±)- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Racemic mixture (≥ 99:1 dr)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.