Description

(2,2-Difluoro-Ethyl)-Methyl-Amine is a versatile fluorinated amine building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoroethyl group, enabling the introduction of fluorine atoms to modulate the physicochemical properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Ligand and Catalyst Development: Used in the synthesis of specialized fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Intermediate in the production of fluorinated polymers, surfactants, and specialty materials with unique surface properties.
• PET Tracer Synthesis: Potential precursor in radiochemistry for developing fluorine-18 labeled positron emission tomography (PET) imaging agents.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biomolecules for studying biological pathways and protein interactions.

Basic Information

Item	Detail
Product Name	(2,2-Difluoro-Ethyl)-Methyl-Amine
CAS No.	60168-06-1
Molecular Formula	C₃H₇F₂N
Molecular Weight	95.09 g/mol
Synonyms	N-Methyl-2,2-difluoroethylamine; 2,2-Difluoro-N-methylethanamine; N-Methyl-2,2-difluoroethanamine; 2,2-Difluoroethyl(methyl)amine; Methyl(2,2-difluoroethyl)amine; 1,1-Difluoro-2-(methylamino)ethane; (2,2-Difluoroethyl)methylamine
EINECS	Contact for details

Quality Control

Every batch of (2,2-Difluoro-Ethyl)-Methyl-Amine is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing purity (typically ≥95% by GC or HPLC), identity confirmation, and impurity profile is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile and basic nature, keep away from heat, sparks, open flames, and strong oxidizing agents. Use appropriate grounding and bonding procedures during handling and transfer.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.