Description

(R)-2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide is a high-purity, stereochemically defined pharmaceutical intermediate of significant importance in advanced medicinal chemistry. This compound serves as a critical chiral building block for the synthesis of targeted therapeutic agents, particularly in oncology research. It is essential for pharmaceutical manufacturers and advanced research institutions developing next-generation chemotherapeutic and cytostatic drugs, where precise stereochemistry is paramount for biological activity and efficacy.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of sophisticated active pharmaceutical ingredients (APIs), especially nitrogen mustard-based chemotherapeutic agents.
• Oncology Research: Critical for the research and development of novel alkylating agents and targeted cancer therapies that require the specific (R)-enantiomer for optimal interaction with biological targets.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and the development of prodrugs with improved selectivity and reduced side-effect profiles.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and optimization of synthetic routes for complex drug molecules under Good Manufacturing Practice (GMP) guidelines.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems due to its reactive chloroethyl groups.

Basic Information

Item	Details
Product Name	(R)-2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide
CAS No.	60030-72-0
Molecular Formula	C7H15Cl2N2O2P
Molecular Weight	261.09 g/mol
Synonyms	(R)-Cyclophosphamide Impurity; (R)-Cyclophosphamide; (R)-N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide; (R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; (R)-CPA; (R)-N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; (R)-Bis(2-chloroethyl)amino-1,3,2-oxazaphosphorinane 2-oxide; (R)-Cyclophosphamide Related Compound R
EINECS	Contact for details

Quality Control

Our production of (R)-2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide adheres to stringent quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles. We can supply material that meets the specifications required for use as a pharmaceutical reference standard or advanced intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.