Description

(S)-2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide is a high-purity, chiral oxazaphosphorine derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate and a potential precursor for novel therapeutic agents, particularly in the field of oncology and targeted drug delivery. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the synthesis of specialized active pharmaceutical ingredients (APIs) and prodrugs.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of chiral, nitrogen mustard-based chemotherapeutic agents and prodrugs.
• Oncology Research: Used as a precursor or model compound in the development of novel alkylating agents with targeted activity.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce side effects.
• Prodrug Development: Exploited in the design of bioreversible derivatives to improve the selectivity and pharmacokinetic profile of cytotoxic drugs.
• Chemical Biology: Utilized as a tool compound to study DNA alkylation mechanisms and cellular response pathways.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a stereochemically defined phosphoramide core.

Basic Information

Product Name	(S)-2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide
CAS No.	60007-96-7
Molecular Formula	C7H15Cl2N2O2P
Molecular Weight	261.09 g/mol
Synonyms	(S)-Cyclophosphamide; (S)-N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide; (S)-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; (S)-CPA; L-Cyclophosphamide; (-)-Cyclophosphamide; (S)-Cyclophosphamide Monohydrate (when applicable); NSC-26271 (S-enantiomer)
EINECS	Contact for details

Quality Control

Every batch of (S)-2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research intermediates. Certificates of Analysis (COA) detailing specifications such as chiral purity, assay, and related substances are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.