Description

Cyclophosphamide is a potent nitrogen mustard alkylating agent and a cornerstone prodrug in the class of oxazaphosphorine chemotherapeutic agents. Its primary value lies in its ability to interfere with DNA replication and transcription, making it a critical component in various immunosuppressive and antineoplastic treatment regimens. This compound is essential for pharmaceutical manufacturers, research institutions, and compounding pharmacies engaged in oncology, autoimmune disease therapy, and transplant medicine. Cyclophosphamide CAS NO 60007-95-6 is supplied under stringent quality controls to ensure reliability for sensitive applications.

Application

• Oncological Chemotherapy: A key agent in the treatment of various cancers, including lymphomas, leukemias, multiple myeloma, and solid tumors such as breast and ovarian cancer.
• Immunosuppressive Therapy: Used to manage severe autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis by suppressing aberrant immune activity.
• Conditioning Regimens for Transplant: Employed in high-dose conditioning regimens prior to bone marrow or stem cell transplantation to ablate the recipient's immune system.
• Pharmaceutical Intermediates: Serves as a critical active pharmaceutical ingredient (API) in the manufacture of injectable and oral dosage forms.
• Biomedical Research: Utilized in preclinical and clinical research to study mechanisms of alkylation, DNA damage response, and to develop new combination therapies.

Basic Information

Product Name	Cyclophosphamide
CAS No.	60007-95-6
Molecular Formula	C7H15Cl2N2O2P
Molecular Weight	261.09 g/mol
Synonyms	Cyclophosphamide Monohydrate; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate; CP; CPM; CY; Endoxan; Cytoxan; Neosar; Cycloblastin; Genoxal; Sendoxan; NSC-26271
EINECS	Contact for details

Quality Control

Our Cyclophosphamide is manufactured and tested to meet exacting standards for pharmaceutical use. Quality assurance includes comprehensive analytical testing against specifications for identity, purity, and impurities, referencing pharmacopeial guidelines where applicable. A Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and other critical parameters. We support compliance with cGMP, ICH guidelines, and relevant regulatory frameworks (e.g., FDA, EMA) for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions that minimize exposure to humidity and temperature fluctuations.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.