Description

4-Trimethylsilyl-3-Butyn-2-Ol CAS NO 6999-19-5 is a versatile organosilicon-protected acetylene alcohol, serving as a critical building block in advanced organic synthesis. Its value lies in the dual functionality of the silyl-protected alkyne and the alcohol group, enabling precise and efficient carbon-carbon bond formation. This compound is essential for researchers and manufacturers in pharmaceutical, agrochemical, and specialty chemical sectors who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug molecules, particularly those requiring alkyne coupling reactions (e.g., Sonogashira coupling).
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and pesticides that incorporate acetylene functionalities.
• Material Science Precursor: Employed in the development of specialty polymers, dendrimers, and organic electronic materials.
• Cross-Coupling Reactions: Acts as a stable, protected acetylene source in Pd-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Natural Product Synthesis: Facilitates the construction of complex natural product skeletons found in bioactive compounds.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel ligands and organometallic catalysts.

Basic Information

Product Name	4-Trimethylsilyl-3-Butyn-2-Ol
CAS No.	6999-19-5
Molecular Formula	C7H14OSi
Molecular Weight	142.27 g/mol
Synonyms	3-Butyn-2-ol, 4-(trimethylsilyl)-; 4-(Trimethylsilyl)-3-butyn-2-ol; 1-Trimethylsilyl-1-butyn-3-ol; 2-Hydroxy-4-(trimethylsilyl)-2-butyne; TMS-Protected Butynol; Trimethyl(3-hydroxy-1-butyn-1-yl)silane; 3-Butyn-2-ol, 4-(trimethylsilyl)-, (R*,S*)-(±)-; (RS)-4-Trimethylsilyl-3-butyn-2-ol
EINECS	Contact for details

Quality Control

Our production of 4-Trimethylsilyl-3-Butyn-2-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (GC, HPLC, NMR) to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting compliance in regulated synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.