Description

1-Bromo-4-Trimethylsilylbenzene is a versatile organosilicon building block that combines a reactive bromoarene moiety with a stable, lipophilic trimethylsilyl (TMS) protecting group. This compound matters for its pivotal role in modern synthetic chemistry, enabling precise cross-coupling reactions and serving as a key intermediate in the development of advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura and Other Cross-Coupling Reactions: Serves as a critical electrophilic partner for palladium-catalyzed couplings to introduce the 4-(trimethylsilyl)phenyl group into target molecules.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring silicon-containing aromatic systems for enhanced metabolic stability or lipophilicity.
• Liquid Crystal and OLED Material Synthesis: Acts as a precursor for constructing silicon-based aromatic cores essential in advanced electronic and display materials.
• Agrochemical Synthesis: Employed in creating novel pesticides and herbicides where the TMS group can modify biological activity and environmental persistence.
• Polymer and Dendrimer Chemistry: Functions as a monomer or branching unit for creating silicon-functionalized polymers with specific thermal or optical properties.
• Organic Synthesis Reagent: Utilized as a versatile reagent for introducing protecting groups or as a traceless linker in multi-step synthetic sequences.

Basic Information

Product Name	1-Bromo-4-Trimethylsilylbenzene
CAS No.	6999-03-7
Molecular Formula	C9H13BrSi
Molecular Weight	229.19 g/mol
Synonyms	4-Bromophenyltrimethylsilane; p-Bromophenyltrimethylsilane; (4-Bromophenyl)trimethylsilane; Trimethyl(4-bromophenyl)silane; TMS-Ph-Br; 4-Bromo-1-(trimethylsilyl)benzene; Bromo(trimethylsilyl)benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Trimethylsilylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.