Description

3-o-Acetyl-5-Deoxy-1-O,2-o-Isopropylidene-β-L-Threo-Penta-4-Enofuranose is a high-purity, advanced pharmaceutical intermediate and chiral building block. This compound is valued for its role in the synthesis of complex nucleoside analogues and carbohydrate-based therapeutics, offering a critical stereochemical handle for medicinal chemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing antiviral drugs and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Carbohydrate Chemistry Research: Serves as a protected, functionalized sugar derivative for studying glycosylation reactions and synthesizing complex oligosaccharides.
• Antiviral Drug Development: Used in the research and production of experimental therapeutics targeting viruses such as HIV and hepatitis.
• Chiral Building Block: Provides a defined stereocenter for the asymmetric synthesis of biologically active compounds in medicinal chemistry programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Synthesis: Useful for creating labeled carbohydrate probes for biochemical and diagnostic applications.

Basic Information

Item	Details
Product Name	3-o-Acetyl-5-Deoxy-1-O,2-o-Isopropylidene-β-L-Threo-Penta-4-Enofuranose
CAS No.	6983-39-7
Molecular Formula	C12H16O6
Molecular Weight	256.25 g/mol
Synonyms	1,2-O-Isopropylidene-3-O-acetyl-5-deoxy-β-L-threo-pent-4-enofuranose; 3-O-Acetyl-5-deoxy-1,2-O-isopropylidene-β-L-threo-pent-4-enofuranose; 5-Deoxy-1,2-O-isopropylidene-3-O-acetyl-β-L-threo-pent-4-enofuranose; L-Threo-pent-4-enofuranose, 3-O-acetyl-5-deoxy-1,2-O-isopropylidene-, β-; Acetylated Isopropylidene Pentenofuranose; β-L-Threo Pentenofuranose Derivative
EINECS	Contact for details

Quality Control

Our 3-o-Acetyl-5-Deoxy-1-O,2-o-Isopropylidene-β-L-Threo-Penta-4-Enofuranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.