Description

2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Glucose is a fully protected derivative of D-glucose, where all hydroxyl groups are silylated with trimethylsilyl (TMS) groups. This chemical modification is critical for its role as a versatile intermediate and protecting group reagent in sophisticated organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex carbohydrate-based molecules and nucleosides.

Application

• Key Intermediate in Nucleoside & Carbohydrate Synthesis: Serves as a protected glucose building block for the production of modified nucleosides, antiviral agents, and complex oligosaccharides.
• Glycosylation Reactions: Used in the preparation of glycosyl donors and acceptors for constructing specific glycosidic linkages under controlled conditions.
• Pharmaceutical Research: Employed in the discovery and development of new drug candidates, particularly those targeting metabolic pathways or requiring sugar moieties.
• Process Chemistry & Scale-up: Provides a stable, soluble form of glucose for multi-step synthetic routes in pilot plant and commercial manufacturing.
• Chiral Pool Synthesis: Utilized as a source of chirality for the asymmetric synthesis of non-carbohydrate natural products and active pharmaceutical ingredients (APIs).
• Analytical Standard & Reference Material: Acts as a high-purity standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Glucose
CAS No.	6736-97-6
Molecular Formula	C24H58O6Si5
Molecular Weight	595.18 g/mol
Synonyms	D-Glucose, pentakis-O-(trimethylsilyl) ether; Pentakis-O-(trimethylsilyl)-D-glucopyranose; 1,2,3,4,6-Penta-O-trimethylsilyl-D-glucose; TMS-Glucose; D-Glucose penta-TMS ether; Per-O-trimethylsilyl-D-glucose; Glucose pentatrimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Glucose is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Quality is assured through a battery of analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.