Description

2-Chloro-5-Nitro-Pyridine-3-Sulfonyl Chloride is a versatile and highly reactive chemical intermediate, primarily valued for its dual functional groups which enable selective derivatization in complex organic syntheses. This compound is essential for the development of advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where it serves as a key building block. It is specifically sought after by R&D chemists and process development scientists working on sulfonamide-based active ingredients, heterocyclic chemistry, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those containing sulfonamide pharmacophores for therapeutic areas like oncology, anti-infectives, and CNS disorders.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the pyridine-sulfonyl chloride moiety contributes to biological activity and selectivity.
• Functional Material Development: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials requiring specific sulfonyl chloride reactivity.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new reaction pathways and creating libraries of sulfonamide derivatives for screening.
• Dye and Pigment Industry: Acts as an intermediate in the production of complex, high-performance dyes and pigments.

Basic Information

Product Name	2-Chloro-5-Nitro-Pyridine-3-Sulfonyl Chloride
CAS No.	6684-05-5
Molecular Formula	C5H2Cl2N2O4S
Molecular Weight	256.05 g/mol
Synonyms	3-Chlorosulfonyl-2-chloro-5-nitropyridine; 2-Chloro-5-nitropyridine-3-sulfonyl chloride; 5-Nitro-2-chloropyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride, 2-chloro-5-nitro-; 2-Chloro-3-(chlorosulfonyl)-5-nitropyridine; 5-Nitro-2,3-dichlorosulfonylpyridine; 6684-05-5 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Nitro-Pyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and amines.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.