Description

(E)-3'-Methoxy-2',3,4,4'-Tetrahydroxychalcone is a specialized polyphenolic chalcone derivative of significant interest in advanced research and development. This compound serves as a valuable high-purity reference standard and key synthetic intermediate for pharmaceutical and nutraceutical applications. It is primarily needed by R&D laboratories and manufacturers in the pharmaceutical, cosmetic, and functional food ingredient sectors, where its bioactive properties are under investigation.

Application

• Pharmaceutical Research Intermediate: Serves as a key building block in the synthesis of novel drug candidates targeting inflammation and metabolic disorders.
• Reference Standard for Analytical Testing: Used as a high-purity calibrant in HPLC, LC-MS, and NMR for quality control and method development in analytical laboratories.
• Cosmeceutical Active Ingredient: Investigated for its potential antioxidant and skin-brightening properties in advanced skincare formulations.
• Nutraceutical and Functional Food Research: Studied as a potential bioactive component in dietary supplements for its purported health benefits.
• Biochemical Research Reagent: Utilized in in-vitro studies to explore mechanisms of action related to its biological activity.
• Chemical Synthesis Building Block: Employed in organic synthesis to create more complex polyphenolic or flavonoid derivatives.

Basic Information

Product Name	(E)-3'-Methoxy-2',3,4,4'-Tetrahydroxychalcone
CAS No.	6542-59-2
Molecular Formula	C₁₆H₁₄O₆
Molecular Weight	302.28 g/mol
Synonyms	3'-Methoxy-2',3,4,4'-Tetrahydroxychalcone; 2-Propen-1-one, 1-(2,3,4-trihydroxyphenyl)-3-(3-methoxyphenyl)-, (E)-; (E)-1-(2,3,4-Trihydroxyphenyl)-3-(3-methoxyphenyl)-2-propen-1-one; 3'-Methoxy-2',3,4,4'-Tetrahydroxychalcone (E)-isomer; NSC 407347; Chalcone derivative 6542-59-2
EINECS	Contact for details

Quality Control

Our (E)-3'-Methoxy-2',3,4,4'-Tetrahydroxychalcone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to ensure full traceability and compliance with your research or manufacturing standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its light-sensitive and easily oxidized nature, prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.