Description

Triisobutylsilane is a versatile organosilicon compound with the CAS number 6485-81-0, widely recognized for its utility as a reducing agent and a versatile building block in organic synthesis. Its primary value lies in its ability to act as a mild and selective hydride source, making it indispensable for chemists performing critical functional group transformations. This chemical is essential for R&D laboratories and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors, where precise and efficient synthesis is paramount.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent in the production of active pharmaceutical ingredients (APIs), particularly for reduction reactions.
• Cross-Coupling Reactions: Used as a mild reducing agent in palladium-catalyzed processes and other metal-mediated couplings.
• Surface Modification & Silane Coupling Agent: Imparts hydrophobic properties to surfaces and acts as a precursor for functionalized silanes in material science.
• Polymer & Resin Manufacturing: Serves as a chain transfer agent or modifier in the synthesis of specialty silicones and polymers.
• Deoxygenation & Dehalogenation Reactions: Employed for the selective removal of oxygen or halogen atoms from complex molecules.
• Laboratory Research & Process Development: A staple reagent in organic chemistry labs for method development and scale-up studies.

Basic Information

Item	Detail
Product Name	Triisobutylsilane
CAS No.	6485-81-0
Molecular Formula	C12H28Si
Molecular Weight	200.44 g/mol
Synonyms	Triisobutylsilane; Triisobutylsilyl hydride; TIBS; Triisobutylsilicon hydride; Hydridotriisobutylsilane; Silane, triisobutyl-; (i-Bu)3SiH; Tri-sec-butylsilane (related isomer)
EINECS	229-355-8

Quality Control

Our Triisobutylsilane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	0.78 - 0.80 g/mL
Refractive Index (n20/D)	1.430 - 1.435

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.