Description

2-Ethyl-2-Phenylglycine Ethyl Ester is a high-purity, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, phenyl-substituted glycine scaffold essential for constructing complex molecules with specific stereochemistry. This compound is primarily needed by research and development laboratories, as well as production facilities, in the pharmaceutical and agrochemical industries for applications such as peptide mimetics and active pharmaceutical ingredient (API) intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting the central nervous system.
• Peptidomimetic Research: Used to incorporate sterically hindered, non-proteinogenic amino acid residues into peptide analogs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing advanced herbicides and pesticides with specific chiral activity.
• Asymmetric Catalysis Ligand Precursor: Utilized in the development of chiral ligands for asymmetric hydrogenation and other catalytic transformations.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	2-Ethyl-2-Phenylglycine Ethyl Ester
CAS No.	6480-87-1
Molecular Formula	C₁₂H₁₇NO₂
Molecular Weight	207.27 g/mol
Synonyms	Ethyl 2-ethyl-2-phenylglycinate; 2-Phenyl-2-ethylaminoacetic Acid Ethyl Ester; DL-2-Ethyl-2-phenylglycine Ethyl Ester; Glycine, 2-ethyl-2-phenyl-, ethyl ester; Ethyl α-ethyl-α-phenylglycinate; α-Ethyl-α-phenylglycine ethyl ester; (RS)-2-Ethyl-2-phenylglycine ethyl ester; Amino acid ester derivative
EINECS	Contact for details

Quality Control

Our 2-Ethyl-2-Phenylglycine Ethyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	Contact for details (Racemic or Enantiopure grades available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.