Description

Chrysamine G CAS NO 6472-91-9 is a synthetic, anionic azo dye known for its specific affinity for amyloid fibrils, making it a critical diagnostic and research reagent. This compound is valued for its high selectivity and sensitivity in histopathological staining, enabling clear visualization of protein aggregates. It is primarily utilized by research institutions, diagnostic laboratories, and pharmaceutical developers focused on neurodegenerative diseases and protein misfolding disorders.

Application

• Histopathological Staining: Primary application for the detection and visualization of amyloid plaques in tissue sections from brain and other organs.
• Neurodegenerative Disease Research: Essential tool in Alzheimer's disease, Parkinson's disease, and prion disease research for studying protein aggregation pathology.
• In Vitro Assays: Used in fluorescence-based or colorimetric assays to quantify amyloid fibril formation in solution.
• Drug Discovery Screening: Employed in high-throughput screening platforms to identify compounds that inhibit or disrupt amyloid aggregation.
• Biomedical Imaging: Potential use as a contrast agent in ex vivo imaging studies of amyloid deposits.
• Quality Control for Antibody Production: Can be used to validate the specificity of anti-amyloid antibodies.

Basic Information

Product Name	Chrysamine G
CAS No.	6472-91-9
Molecular Formula	C32H24N6O8S2Na2
Molecular Weight	726.68 g/mol
Synonyms	Direct Yellow 7; Chicago Sky Blue 6B; Pontamine Sky Blue 6BX; C.I. 24890; Sodium 4,4'-[carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis(5-hydroxy-2,7-naphthalenedisulfonate); Benzenesulfonic acid, 4,4'-[carbonylbis[imino(4-hydroxy-2,1-phenylene)carbonylimino(4-hydroxy-2,1-phenylene)carbonylimino]]bis[5-hydroxy-6-[(4-sulfophenyl)azo]-, sodium salt (1:4)
EINECS	229-314-2

Quality Control

Our Chrysamine G is produced and tested under a strict quality management system to ensure batch-to-batch consistency for research and diagnostic applications. Each lot undergoes comprehensive analysis, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) documenting purity, absorbance characteristics, and performance in a standard staining protocol is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Dark blue to black powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Absorbance Max (λmax)	610 - 630 nm (in aqueous solution)
Performance (Staining)	Produces characteristic red fluorescence of amyloid plaques under appropriate conditions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.