Description

tert-Butyl Glycinate is a versatile and protected amino acid ester widely used as a key synthetic intermediate in organic chemistry. Its primary value lies in its role as a crucial building block for the synthesis of peptides, pharmaceuticals, and fine chemicals, offering a stable tert-butyl ester protecting group that can be selectively removed under mild acidic conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and biotechnology sectors who require high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and small molecule therapeutics.
• Peptide Synthesis: Used extensively in solid-phase and solution-phase peptide synthesis as a protected glycine derivative to prevent unwanted side reactions.
• Agrochemical Production: Serves as a precursor in the manufacture of certain herbicides, pesticides, and plant growth regulators.
• Fine Chemical Synthesis: Employed in the preparation of complex organic molecules, including dyes, flavors, and fragrances.
• Bioconjugation & Linker Chemistry: Utilized in the development of bioconjugates, antibody-drug conjugates (ADCs), and chemical linkers for drug delivery systems.
• Research & Development: A valuable reagent in academic and industrial R&D labs for method development and exploring new synthetic pathways.

Basic Information

Product Name	tert-Butyl Glycinate
CAS No.	6456-74-2
Molecular Formula	C6H13NO2
Molecular Weight	131.17 g/mol
Synonyms	Glycine, 1,1-dimethylethyl ester; tert-Butyl aminoacetate; 2-[(tert-Butoxycarbonyl)amino]acetic acid; N-(tert-Butoxycarbonyl)glycine; Boc-Gly-OH; Boc-Glycine; Aminoacetic acid tert-butyl ester; t-Butyl glycinate
EINECS	229-267-9

Quality Control

Our tert-Butyl Glycinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade specifications suitable for pharmaceutical and research applications. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	86 - 90 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.