Description

3,5-Dimethoxybenzyl 4-Nitrophenyl Carbonate is a specialized chemical reagent primarily used as a versatile building block and protecting group in advanced organic synthesis. Its core value lies in its reactivity as a carbonate ester, enabling controlled acylation and the introduction of the 3,5-dimethoxybenzyl moiety, a valuable functional group in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly those requiring the 3,5-dimethoxybenzyl protecting group or functional handle.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) as a reagent for the temporary protection of amino groups or for specific side-chain modifications.
• Protecting Group Reagent: Serves as a 3,5-dimethoxybenzyloxycarbonyl (Dmz) group donor for the protection of alcohols, amines, and other nucleophiles in multi-step syntheses.
• Bioconjugation: Employed in the functionalization of biomolecules, such as proteins or oligonucleotides, for creating labeled probes or drug conjugates.
• Material Science Research: Utilized in the development of novel polymers or dendritic structures where controlled, sequential coupling reactions are required.
• Agrochemical Synthesis: Intermediate in the research and development of new herbicides, fungicides, or plant growth regulators.

Basic Information

Item	Details
Product Name	3,5-Dimethoxybenzyl 4-Nitrophenyl Carbonate
CAS No.	6453-62-9
Molecular Formula	C16H15NO7
Molecular Weight	333.30 g/mol
Synonyms	4-Nitrophenyl 3,5-Dimethoxybenzyl Carbonate; 3,5-Dimethoxybenzyl Alcohol 4-Nitrophenyl Carbonate; Dmz-ONp; (3,5-Dimethoxyphenyl)methyl (4-nitrophenyl) carbonate; 4-Nitrophenyl Carbonate of 3,5-Dimethoxybenzyl Alcohol; NSC 334082; Carbonochloridic acid, (3,5-dimethoxyphenyl)methyl ester, 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our 3,5-Dimethoxybenzyl 4-Nitrophenyl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under inert atmosphere for long-term storage to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.