Description

D-Phenylalanine, 1,1-Dimethylethyl Ester is a protected derivative of the non-natural D-enantiomer of the essential amino acid phenylalanine. This compound serves as a crucial chiral building block and intermediate in the synthesis of complex peptides and pharmaceutical active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the asymmetric synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the tert-butyl ester group provides orthogonal protection for the carboxylic acid functionality.
• Proteomics & Biochemical Research: Essential reagent for studying enzyme specificity, metabolic pathways, and for the preparation of non-hydrolyzable peptide analogs.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & R&D: Serves as a standard or starting material in organic chemistry research focused on stereoselective synthesis and medicinal chemistry.

Basic Information

Product Name	D-Phenylalanine, 1,1-Dimethylethyl Ester
CAS No.	6404-30-4
Molecular Formula	C₁₃H₁₉NO₂
Molecular Weight	221.30 g/mol
Synonyms	D-Phenylalanine tert-butyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid; tert-Butyl D-phenylalaninate; D-Phe-OtBu; Boc-D-Phe-OtBu (when referring to N-Boc protected variant); (R)-2-Amino-3-phenylpropanoic acid 1,1-dimethylethyl ester; D-α-Aminohydrocinnamic acid tert-butyl ester; Fmoc-D-Phe-OtBu (when referring to N-Fmoc protected variant)
EINECS	Contact for details

Quality Control

Our D-Phenylalanine, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.