Description

Amodiaquin Dihydrochloride Dihydrate is a high-purity pharmaceutical salt form of the antimalarial compound amodiaquine. This compound matters as a critical reference standard and active pharmaceutical ingredient (API) intermediate for research and development in tropical medicine. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development, quality control, and production of antimalarial therapeutics.

Application

• Pharmaceutical API Intermediate: Serves as a key starting material or intermediate in the synthesis of antimalarial drug formulations.
• Analytical Reference Standard: Used for method development, validation, and quality control testing (e.g., HPLC, LC-MS) in pharmaceutical analysis.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate mechanisms of action, resistance, and efficacy against Plasmodium parasites.
• Pharmacopoeial Testing: Acts as a certified reference material for compliance testing against USP, EP, or other pharmacopoeial monographs.
• Impurity Profiling: Utilized to identify and quantify related substances and degradation products in amodiaquine-based drug products.
• Chemical Synthesis: Provides a dihydrochloride salt form for improved stability and handling in further synthetic transformations.

Basic Information

Product Name	Amodiaquin Dihydrochloride Dihydrate
CAS No.	6398-98-7
Molecular Formula	C20H25ClN3O · 2HCl · 2H2O
Molecular Weight	464.86 g/mol (Anhydrous free base: 355.89)
Synonyms	Amodiaquine Dihydrochloride Dihydrate; 4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol Dihydrochloride Dihydrate; Amodiaquin HCl Dihydrate; Amodiaquine 2HCl Dihydrate; Camoquin Dihydrochloride; SN-10751 Dihydrochloride Dihydrate; Phenol, 4-[(7-chloro-4-quinolyl)amino]-2-[(diethylamino)methyl]-, dihydrochloride, dihydrate
EINECS	Contact for details

Quality Control

Our Amodiaquin Dihydrochloride Dihydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical research and development. Certificates of Analysis (COA) detailing comprehensive test results, including HPLC purity, related substances, and residual solvents, are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	6.5% - 8.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.