Description

Bis(Iodoacetic Acid)(1R,2S)-1,2-Dimethyl-1,2-Ethanediyl Ester is a specialized chiral organic compound featuring two iodoacetate groups, making it a valuable bifunctional alkylating agent and a key synthetic intermediate. Its precise stereochemistry and reactive iodine atoms are critical for applications requiring controlled cross-linking, site-specific modification, or the construction of complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in advanced pharmaceutical development, asymmetric synthesis, and the creation of novel materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of chiral active pharmaceutical ingredients (APIs) and complex drug candidates, particularly in oncology and targeted therapies.
• Bioconjugation Reagent: Acts as a cross-linker for modifying proteins, peptides, and antibodies, enabling the study of protein structure-function relationships and the development of antibody-drug conjugates (ADCs).
• Asymmetric Synthesis: Serves as a chiral building block for constructing stereochemically defined compounds in organic and medicinal chemistry research.
• Polymer Chemistry: Employed as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme mechanisms and metabolic pathways.
• Material Science: Applied in the surface functionalization of nanomaterials and the synthesis of advanced organic frameworks.

Basic Information

Product Name	Bis(Iodoacetic Acid)(1R,2S)-1,2-Dimethyl-1,2-Ethanediyl Ester
CAS No.	6305-45-9
Molecular Formula	C8H12I2O4
Molecular Weight	425.99 g/mol
Synonyms	(1R,2S)-1,2-Dimethyl-1,2-ethanediyl bis(2-iodoacetate); 1,2-Dimethylethylene diiodoacetate; Diiodoacetic acid (1R,2S)-1,2-dimethylethylene ester; (1R,2S)-(-)-1,2-Dimethylethylene diiodoacetate; Iodoacetic acid (1R,2S)-1,2-dimethylethylene diester; (R,S)-Dimethylethylene diiodoacetate; Bis(2-iodoacetyl) (1R,2S)-1,2-dimethylethylene
EINECS	Contact for details

Quality Control

Our Bis(Iodoacetic Acid)(1R,2S)-1,2-Dimethyl-1,2-Ethanediyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be performed under subdued lighting or in amber glass containers to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% de
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.