Description

6-Chloronicotinamide is a versatile halogenated nicotinamide derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its reactive chloropyridine core, which enables precise chemical modifications for creating complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of nicotinamide-based drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, leveraging its halogenated pyridine structure.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the development of functional organic materials and molecular scaffolds.
• Chemical Biology Probes: Utilized in the design and synthesis of probes for studying biological processes and enzyme functions.
• Custom Synthesis and R&D: A fundamental starting material for contract research organizations and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	6-Chloronicotinamide
CAS No.	6271-78-9
Molecular Formula	C6H5ClN2O
Molecular Weight	156.57 g/mol
Synonyms	6-Chloropyridine-3-carboxamide; 3-Carbamoyl-6-chloropyridine; Nicotinamide, 6-chloro-; 6-Chloro-3-pyridinecarboxamide; 6-Chloro-nicotinamide; 2-Chloro-5-carbamoylpyridine; 6-Chloronicotinic acid amide
EINECS	Contact for details

Quality Control

Our 6-Chloronicotinamide is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.