Description

1-Azabicyclo[2.2.2]Oct-2-Ene-3-Carboxylic Acid Ethyl Ester is a versatile bicyclic tertiary amine and ester derivative that serves as a crucial advanced pharmaceutical intermediate and a valuable scaffold in synthetic organic chemistry. Its unique, rigid molecular framework makes it an essential building block for constructing complex molecules with specific three-dimensional architectures. This compound is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients and specialized ligands.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS).
• Organocatalyst Synthesis: Used to construct chiral amine-based catalysts for asymmetric synthesis applications.
• Ligand Building Block: Serves as a core structure for developing novel ligands in coordination chemistry and catalysis.
• Alkaloid Analog Synthesis: Employed in the research and synthesis of natural product analogs and novel bioactive compounds.
• Polymer Chemistry: Can be utilized as a monomer or functionalizing agent for creating specialty polymers with amine functionality.
• Academic & Industrial Research: A valuable tool compound for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Item	Detail
Product Name	1-Azabicyclo[2.2.2]Oct-2-Ene-3-Carboxylic Acid Ethyl Ester
CAS No.	6238-32-0
Molecular Formula	C10H15NO2
Molecular Weight	181.23 g/mol
Synonyms	Ethyl 1-Azabicyclo[2.2.2]oct-2-ene-3-carboxylate; 3-Quinuclidinecarboxylic acid ethyl ester; 1-Azabicyclo[2.2.2]oct-2-ene-3-carboxylic acid ethyl ester; Ethyl 3-quinuclidinecarboxylate; 2-Quinuclidinecarboxylic acid ethyl ester (common misnomer); Bicyclic amine ester; Quinuclidine derivative ethyl ester
EINECS	Contact for details

Quality Control

We maintain a strict quality management system to ensure batch-to-batch consistency and high purity. Our standard grade for this intermediate typically meets a purity specification of ≥97% (by HPLC), suitable for research and further synthetic steps. Identity is confirmed via spectroscopic methods (IR, NMR). A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Custom purification to meet specific project requirements (e.g., >99% purity) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and acids. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.