Description

(S)-(+)-Citramalic Acid is a high-purity, single-enantiomer chiral building block and intermediate of significant value in asymmetric synthesis. Its stereochemical purity makes it a critical component for producing optically active compounds where specific handedness is required. This product is essential for research and development laboratories, as well as production facilities in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Catalyst Ligand Precursor: Used to develop and manufacture chiral ligands for metal-catalyzed reactions, enhancing selectivity and yield.
• Agrochemical Synthesis: Employed in the production of chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Fine Chemical Building Block: Serves as a starting material for complex natural products, flavors, and fragrances requiring specific stereochemistry.
• Biochemical Research: Used in enzymatic studies and as a standard or reagent in metabolic pathway analysis.
• Academic & Industrial R&D: A valuable tool for chemists exploring new synthetic methodologies and chiral pool applications.

Basic Information

Product Name	(S)-(+)-Citramalic Acid
CAS No.	6236-09-5
Molecular Formula	C5H8O5
Molecular Weight	148.11 g/mol
Synonyms	(S)-2-Hydroxy-2-methylbutanedioic acid; (S)-2-Methylmalic acid; (S)-(+)-2-Methylmalic acid; L-Citramalic acid; (S)-Citramalic acid; (+)-Citramalic acid; (2S)-2-Hydroxy-2-methylsuccinic acid; 2-Methyl-DL-malic acid (S-enantiomer)
EINECS	228-354-9

Quality Control

Our (S)-(+)-Citramalic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, identity confirmation by IR and NMR, and purity assessment. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	115°C - 120°C
Specific Rotation ([α]D20)	+14.0° to +16.0° (c=1 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.