Description

2,2,2-Trifluoroethyl Trifluoromethanesulfonate is a highly reactive trifluoromethanesulfonate (triflate) ester, serving as a powerful alkylating and trifluoromethylating agent. Its value lies in introducing the 2,2,2-trifluoroethyl group, a key fluorinated moiety that enhances metabolic stability, lipophilicity, and bioavailability in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for synthesizing novel fluorinated compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Fluorinated Material Production: Serves as a monomer or modifier in the development of specialty polymers, coatings, and liquid crystals.
• Organic Synthesis Reagent: Employed as a versatile reagent for introducing the 2,2,2-trifluoroethyl group in complex molecule construction.
• Laboratory Research: Critical for medicinal chemistry and process development in R&D settings exploring fluorochemistry.
• Fine Chemical Manufacturing: Utilized in the production of high-value fluorinated fine chemicals and custom synthesis projects.

Basic Information

Product Name	2,2,2-Trifluoroethyl Trifluoromethanesulfonate
CAS No.	6226-25-1
Molecular Formula	C3H2F6O3S
Molecular Weight	232.10 g/mol
Synonyms	2,2,2-Trifluoroethyl Triflate; Trifluoromethanesulfonic Acid 2,2,2-Trifluoroethyl Ester; 2,2,2-Trifluoroethyl Trifluoromethanesulphonate; 2,2,2-Trifluoroethyl Trifluoromethylsulfonate; 1,1,1-Trifluoro-2-[(trifluoromethyl)sulfonyl]oxyethane; 2,2,2-Trifluoroethyl Ester of Trifluoromethanesulfonic Acid; TFET; Trifluoroethyl Triflate
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroethyl Trifluoromethanesulfonate is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including assay by GC or HPLC and identity confirmation (IR, NMR), to ensure high purity and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.